تیم تخصصی سایه گستر سلامت • Feb 16, 2026
دسته بندی نشده ~3 min read 337 views

What Are Drug Infiltration and Phlebitis?
Drug infiltration occurs when intravenous fluid leaks into surrounding tissue instead of entering the vein, causing swelling, discomfort, and sometimes tissue damage. Severe cases may lead to tissue necrosis. Phlebitis refers to inflammation of the vein wall, commonly accompanied by redness, warmth, and pain along the vein path. If untreated, it may lead to infection or vascular complications. Reducing these complications improves recovery time and lowers healthcare costs.Mechanical Factors Leading to Complications
Incorrect Cannula Size Selection
Using a large cannula in small veins causes friction against the vein wall, increasing the risk of mechanical phlebitis. The recommended approach is always to select the smallest suitable cannula for treatment needs.Improper Cannulation Site
Inserting cannulas near joints such as the elbow or wrist increases movement and the risk of catheter displacement, leading to infiltration.Poor Cannula Stabilization
If the cannula is not properly secured, catheter movement may damage the vein wall and allow bacterial entry.
Chemical Factors That Damage Veins
Drug pH Level
Highly acidic or alkaline drugs may irritate veins and lead to chemical phlebitis.Solution Osmolarity
Hypertonic solutions can draw fluid from vein cells, causing cellular damage and inflammation.Injection Speed
Rapid infusion of irritating medications exposes the vein wall to high concentrations, increasing injury risk.Human and Technical Factors
Improper Cannulation Technique
Repeated punctures weaken veins and increase infiltration risk.Lack of Sterile Practice
Poor hand hygiene or insufficient skin disinfection may introduce bacteria, leading to infectious phlebitis.Patient-Related Factors
Children and elderly patients often have more fragile veins. Chronic conditions such as diabetes and vascular disease also increase complication risk.Comparison: Drug Infiltration vs. Phlebitis
| Feature | Drug Infiltration | Phlebitis |
|---|---|---|
| Temperature | Area feels cold | Area feels warm |
| Appearance | Swelling and pale skin | Redness along the vein |
| Patient Sensation | Pressure or burning | Pain and tenderness |


